2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145542
    Isovalerylcarnitine chloride 139144-12-0 ≥98.0%
    Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils.
    Isovalerylcarnitine chloride
  • HY-153340
    I-152 311343-11-0 98.78%
    I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties.
    I-152
  • HY-158127
    FABP1-IN-1 3048021-44-6 99.95%
    FABP1-IN-1 (44) is a selective FABP1 inhibitor, with an IC50 of 4.46 μM. FABP1-IN-1 (44) can be used for the research of NASH.
    FABP1-IN-1
  • HY-19720A
    Emixustat hydrochloride 1141934-97-5 99.29%
    Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD).
    Emixustat hydrochloride
  • HY-B0135A
    Furosemide sodium 41733-55-5 99.89%
    Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
    Furosemide sodium
  • HY-N0182R
    Fisetin (Standard) 528-48-3 98.47%
    Fisetin (Standard) is the analytical standard of Fisetin. This product is intended for research and analytical applications. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
    Fisetin (Standard)
  • HY-P1806A
    Gastrin I (1-14), human TFA 99.87%
    Gastrin I (1-14), human TFA is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.
    Gastrin I (1-14), human TFA
  • HY-P4146A
    Survodutide TFA 99.62%
    Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
    Survodutide TFA
  • HY-P99614
    Fazpilodemab 2517935-02-1 ≥99.0%
    Fazpilodemab (BFKB8488A) is a humanized, agonistic, bispecific antibody targeting fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD).
    Fazpilodemab
  • HY-101203A
    GJ103 sodium 1459687-96-7 99.46%
    GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations.
    GJ103 sodium
  • HY-103642A
    D-myo-Inositol-1,4,5-triphosphate trisodium 141611-10-1 99.80%
    D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
    D-myo-Inositol-1,4,5-triphosphate trisodium
  • HY-W001996
    6-Hydroxynicotinic acid 5006-66-6 ≥98.0%
    6-Hydroxynicotinic acid is an endogenous metabolite.
    6-Hydroxynicotinic acid
  • HY-W006371
    (2-Aminoethyl)phosphonic acid 2041-14-7 ≥98.0%
    (2-Aminoethyl)phosphonic acid is an endogenous metabolite.
    (2-Aminoethyl)phosphonic acid
  • HY-W014504
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 343-65-7 98.95%
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
  • HY-W017443
    L-Asparagine monohydrate 5794-13-8 ≥99.0%
    L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine monohydrate
  • HY-W021425
    D-Mannosamine hydrochloride 5505-63-5 ≥98.0%
    D-Mannosamine hydrochloride is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells.
    D-Mannosamine hydrochloride
  • HY-W050145
    Levoglucosan 498-07-7 ≥99.0%
    Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature.
    Levoglucosan
  • HY-Y0337S5
    L-Cysteine-d3 214782-32-8 ≥99.0%
    L-Cysteine-d3 is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].
    L-Cysteine-d3
  • HY-17397
    Strontium Ranelate 135459-87-9 99.99%
    Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling.
    Strontium Ranelate
  • HY-103433
    K579 440100-64-1 ≥99.0%
    K579 is a potent and orally active dipeptidyl peptidase IV inhibitor. K579 inhibits the blood glucose elevation. K579 increases the plasma insulin and active forms of glucagon-like peptide-1 (GLP-1). K579 has the potential for the research of diabetic.
    K579
Cat. No. Product Name / Synonyms Application Reactivity